Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells

BACKGROUND: Multidrug resistance (MDR) in cancer is one of the main obstacles in treatment with chemotherapy. Drug efflux through P-glycoprotein is the major mechanism involved in MDR. A potential strategy to provide the best possible clinical outcomes is to develop P-glycoprotein (P-gp) inhibitors...

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Bibliographic Details
Published in:Phytomedicine
Main Authors: Chang, Ying-Tzu, Wang, Charles C.N., Wang, Jiun-Yi, Lee, Tsui-Er, Cheng, Yung-Yi, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Hung, Chin-Chuan
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421864/
https://ncbi.nlm.nih.gov/pubmed/30668405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phymed.2018.09.008
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