Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced lipotoxicity in muscle cells. C57BL/6J (B6) mice and congenic B6.A-(rs3676616-D10Ut...

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Detalhes bibliográficos
Publicado no:J Nutr Metab
Main Authors: Alhindi, Yosra, Vaanholt, Lobke M., Al-Tarrah, Mustafah, Gray, Stuart R., Speakman, John R., Hambly, Catherine, Alanazi, Bader S., Gabriel, Brendan M., Lionikas, Arimantas, Ratkevicius, Aivaras
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421790/
https://ncbi.nlm.nih.gov/pubmed/30944739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8594825
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