Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection

Adoptive transfer of TCR transgenic T cells holds great promise for treating various cancers. So far, mainly semi-randomly integrating vectors have been used to genetically modify T cells. These carry the risk of insertional mutagenesis, and the sole addition of an exogenous TCR potentially results...

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Publicat a:Life Sci Alliance
Autors principals: Albers, Julian J, Ammon, Tim, Gosmann, Dario, Audehm, Stefan, Thoene, Silvia, Winter, Christof, Secci, Ramona, Wolf, Anja, Stelzl, Anja, Steiger, Katja, Ruland, Jürgen, Bassermann, Florian, Kupatt, Christian, Anton, Martina, Krackhardt, Angela M
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421629/
https://ncbi.nlm.nih.gov/pubmed/30877233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900367
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