Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning

The lysosomal enzyme glucocerebrosidase-1 (GCase) catalyzes the cleavage of a major glycolipid glucosylceramide into glucose and ceramide. The absence of fully functional GCase leads to the accumulation of its lipid substrates in lysosomes, causing Gaucher disease, an autosomal recessive disorder th...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Romero, Raquel, Ramanathan, Arvind, Yuen, Tony, Bhowmik, Debsindhu, Mathew, Mehr, Munshi, Lubna Bashir, Javaid, Seher, Bloch, Madison, Lizneva, Daria, Rahimova, Alina, Khan, Ayesha, Taneja, Charit, Kim, Se-Min, Sun, Li, New, Maria I., Haider, Shozeb, Zaidi, Mone
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421449/
https://ncbi.nlm.nih.gov/pubmed/30808805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818411116
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