Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning

The lysosomal enzyme glucocerebrosidase-1 (GCase) catalyzes the cleavage of a major glycolipid glucosylceramide into glucose and ceramide. The absence of fully functional GCase leads to the accumulation of its lipid substrates in lysosomes, causing Gaucher disease, an autosomal recessive disorder th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Romero, Raquel, Ramanathan, Arvind, Yuen, Tony, Bhowmik, Debsindhu, Mathew, Mehr, Munshi, Lubna Bashir, Javaid, Seher, Bloch, Madison, Lizneva, Daria, Rahimova, Alina, Khan, Ayesha, Taneja, Charit, Kim, Se-Min, Sun, Li, New, Maria I., Haider, Shozeb, Zaidi, Mone
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421449/
https://ncbi.nlm.nih.gov/pubmed/30808805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818411116
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