CRISPR-Cas9 Mediated RNase L Knockout Regulates Cellular Function of PK-15 Cells and Increases PRV Replication

Ribonuclease L (RNase L) is an important antiviral endoribonuclease regulated by type I IFN. RNase L is activated by viral infection and dsRNA. Because the role of swine RNase L (sRNase L) is not fully understood, in this study, we generated a sRNase L knockout PK-15 (KO-PK) cell line through the CR...

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Bibliografiske detaljer
Udgivet i:Biomed Res Int
Main Authors: Sui, Chao, Jiang, Dandan, Wu, Xiangju, Cong, Xiaoyan, Li, Feng, Shang, Yingli, Wang, Jinqiu, Liu, Sidang, Shan, Hu, Qi, Jing, Du, Yijun
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421005/
https://ncbi.nlm.nih.gov/pubmed/30941371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7398208
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