BET inhibitors potentiate chemotherapy and killing of SPOP-mutant colon cancer cells via induction of DR5

Bromodomain and extra-terminal domain (BET) family proteins such as BRD4 are epigenetic readers that control expression of a number of oncogenic proteins. Targeting this family of proteins has recently emerged as a promising anticancer approach. BET inhibitors (BETi), either alone or in combination...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Tan, Xiao, Tong, Jingshan, Wang, Yi-Jun, Fletcher, Rochelle, Schoen, Robert E., Yu, Jian, Shen, Liangfang, Zhang, Lin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420862/
https://ncbi.nlm.nih.gov/pubmed/30674532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3223
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