IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic colon epithelium to promote cancer cell proliferation and inhibit apoptosis

The tryptophan-metabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) is frequently overexpressed in epithelial-derived malignancies, where it plays a recognized role in promoting tumor immune tolerance. We previously demonstrated that the IDO1-kynurenine pathway (KP) also directly supports colore...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Bishnupuri, Kumar S, Alvarado, David M., Khouri, Alexander N., Shabsovich, Mark, Chen, Baosheng, Dieckgraefe, Brian K., Ciorba, Matthew A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420842/
https://ncbi.nlm.nih.gov/pubmed/30679179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0668
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