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Alternative polyadenylation of mammalian transcripts is generally deleterious, not adaptive
Alternative polyadenylation (APA) produces from the same gene multiple mature RNAs with varying 3’ ends. Although APA is commonly believed to generate beneficial functional diversity and be adaptive, we hypothesize that most genes have one optimal polyadenylation site and that APA is caused largely...
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| Udgivet i: | Cell Syst |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6420822/ https://ncbi.nlm.nih.gov/pubmed/29886108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.05.007 |
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