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Alternative polyadenylation of mammalian transcripts is generally deleterious, not adaptive
Alternative polyadenylation (APA) produces from the same gene multiple mature RNAs with varying 3’ ends. Although APA is commonly believed to generate beneficial functional diversity and be adaptive, we hypothesize that most genes have one optimal polyadenylation site and that APA is caused largely...
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| Publicado no: | Cell Syst |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6420822/ https://ncbi.nlm.nih.gov/pubmed/29886108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.05.007 |
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