Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence

Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to aberrant end-joining reactions leading to chromosomal fusions and translocations. Human telomeres contain repeated TTAGGG elements, in which the 3’ exposed strand may adopt a G-quadruplex (G4) structure. The gu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:DNA Repair (Amst)
Autores principales: Burra, Silvia, Marasco, Daniela, Malfatti, Matilde Clarissa, Antoniali, Giulia, Virgilio, Antonella, Esposito, Veronica, Demple, Bruce, Galeone, Aldo, Tell, Gianluca
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420783/
https://ncbi.nlm.nih.gov/pubmed/30509560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.11.010
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares