Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is associated with a high frequency of copy number alterations (CNAs) in IKZF1, EBF1, PAX5, CDKN2A/B, RB1, BTG1, ETV6, and/or the PAR1 region (henceforth: B-cell development genes). We aimed to gain insight in the association between...

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Publicat a:Sci Rep
Autors principals: Steeghs, Elisabeth M. P., Boer, Judith M., Hoogkamer, Alex Q., Boeree, Aurélie, de Haas, Valerie, de Groot-Kruseman, Hester A., Horstmann, Martin A., Escherich, Gabriele, Pieters, Rob, den Boer, Monique L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420659/
https://ncbi.nlm.nih.gov/pubmed/30874617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41078-4
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