Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance

Lithium has been shown to have some therapeutic efficacy as an adjunctive treatment for intractable forms of major depression. Activation of mammalian target of rapamycin (mTOR) and inhibition of glycogen synthase kinase-3β (GSK3β) have been implicated in its putative mechanisms of action. These pro...

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Publicat a:Transl Psychiatry
Autors principals: Walker, Adam J., Price, J. Blair, Borreggine, Kristin, Sutor, Shari L., Gogos, Andrea, McGillivray, Jane A., Frye, Mark A., Tye, Susannah J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420640/
https://ncbi.nlm.nih.gov/pubmed/30877268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0434-5
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