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Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation

PURPOSE: To evaluate the efficiency of ovarian tissue treatment with Z-VAD-FMK, a broad-spectrum caspase inhibitor, to prevent follicle loss induced by ischemia/reperfusion injury after transplantation. METHODS: In vitro, granulosa cells were exposed to hypoxic conditions, reproducing early ischemia...

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Detalles Bibliográficos
Publicado en:J Assist Reprod Genet
Main Authors: Fransolet, Maïté, Noël, Laure, Henry, Laurie, Labied, Soraya, Blacher, Silvia, Nisolle, Michelle, Munaut, Carine
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420548/
https://ncbi.nlm.nih.gov/pubmed/30390176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-018-1353-8
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