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In vitro evaluation of the anti-apoptotic drug Z-VAD-FMK on human ovarian granulosa cell lines for further use in ovarian tissue transplantation

PURPOSE: Because ovarian granulosa cells are essential for oocyte survival, we examined three human granulosa cell lines as models to evaluate the ability of the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) to prevent primordial follicle loss after ovarian tiss...

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Detalhes bibliográficos
Publicado no:J Assist Reprod Genet
Main Authors: Fransolet, Maïté, Henry, Laurie, Labied, Soraya, Noël, Agnès, Nisolle, Michelle, Munaut, Carine
Formato: Artigo
Idioma:Inglês
Publicado em: Springer New York 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615917/
https://ncbi.nlm.nih.gov/pubmed/26169075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-015-0536-9
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