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Validating Molecular Dynamics Simulations Against Experimental Observables in Light of Underlying Conformational Ensembles

Far from the static, idealized conformations deposited into structural databases, proteins are highly dynamic molecules that undergo conformational changes on temporal and spatial scales that may span several orders of magnitude. These conformational changes, often intimately connected to the functi...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Childers, Matthew Carter, Daggett, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420231/
https://ncbi.nlm.nih.gov/pubmed/29864281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b02144
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