Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

PURPOSE: Triple negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer. AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a no...

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Udgivet i:PLoS One
Main Authors: Johnson, Jeremy, Rychahou, Piotr, Sviripa, Vitaliy M., Weiss, Heidi L., Liu, Chunming, Watt, David S., Evers, B. Mark
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420029/
https://ncbi.nlm.nih.gov/pubmed/30875375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209392
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