Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival

BACKGROUND: The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evidence implicates the imprinted genes from this locus, DLK1 and MEG3, in the de...

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Dades bibliogràfiques
Publicat a:Clin Epigenetics
Autors principals: Sellers, Zachariah Payne, Bolkun, Lukasz, Kloczko, Janusz, Wojtaszewska, Marzena Liliana, Lewandowski, Krzysztof, Moniuszko, Marcin, Ratajczak, Mariusz Z., Schneider, Gabriela
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6419839/
https://ncbi.nlm.nih.gov/pubmed/30876483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0643-z
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