Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis

Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We analyzed a cohort of 27 histologically-defined ABs using DNA methylation profiling, copy...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Lehman, Norman L., Usubalieva, Aisulu, Lin, Tong, Allen, Sariah J., Tran, Quynh T., Mobley, Bret C., McLendon, Roger E., Schniederjan, Matthew J., Georgescu, Maria-Magdalena, Couce, Marta, Dulai, Mohanpal S., Raisanen, Jack M., Al Abbadi, Mousa, Palmer, Cheryl A., Hattab, Eyas M., Orr, Brent A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6419470/
https://ncbi.nlm.nih.gov/pubmed/30876455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0689-3
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