Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2‐neo mouse rescued by L‐type calcium channel blockers

KEY POINTS: Tymothy syndrome (TS) is a multisystem disorder featuring cardiac arrhythmias, autism and adrenal gland dysfunction that originates from a de novo point mutation in the gene encoding the Cav1.2 (CACNA1C) L‐type channel. To study the role of Cav1.2 channel signals in autism, the autistic...

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Dades bibliogràfiques
Publicat a:J Physiol
Autors principals: Calorio, Chiara, Gavello, Daniela, Guarina, Laura, Salio, Chiara, Sassoè‐Pognetto, Marco, Riganti, Chiara, Bianchi, Federico Tommaso, Hofer, Nadja T., Tuluc, Petronel, Obermair, Gerald J., Defilippi, Paola, Balzac, Fiorella, Turco, Emilia, Bett, Glenna C., Rasmusson, Randall L., Carbone, Emilio
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418779/
https://ncbi.nlm.nih.gov/pubmed/30629744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277487
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