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Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions

KEY POINTS: Wild‐type mice and mice with hepatocyte‐specific or whole‐body deletions of perilipin‐2 (Plin2) were used to define hepatocyte and extra‐hepatocyte effects of altered cellular lipid storage on obesity and non‐alcoholic fatty liver disease (NAFLD) pathophysiology in a Western‐diet (WD) mo...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Orlicky, David J., Libby, Andrew E., Bales, Elise S., McMahan, Rachel H., Monks, Jenifer, La Rosa, Francisco G., McManaman, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418763/
https://ncbi.nlm.nih.gov/pubmed/30536914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277140
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