Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions

KEY POINTS: Wild‐type mice and mice with hepatocyte‐specific or whole‐body deletions of perilipin‐2 (Plin2) were used to define hepatocyte and extra‐hepatocyte effects of altered cellular lipid storage on obesity and non‐alcoholic fatty liver disease (NAFLD) pathophysiology in a Western‐diet (WD) mo...

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Pubblicato in:J Physiol
Autori principali: Orlicky, David J., Libby, Andrew E., Bales, Elise S., McMahan, Rachel H., Monks, Jenifer, La Rosa, Francisco G., McManaman, James L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Endocrine, Nutrition and Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418763/
https://ncbi.nlm.nih.gov/pubmed/30536914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277140
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