μ‐Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid‐induced hyperalgesia

KEY POINTS: μ‐Opioid receptors (MORs) are expressed peripherally and centrally, but the loci of MORs responsible for clinically relevant opioid analgesia are uncertain. Crossing Oprm1 (flox/flox) and Advillin (Cre/+) mice completely ablates MORs in dorsal root ganglion neurons and reduces the MOR ex...

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Veröffentlicht in:J Physiol
Hauptverfasser: Sun, Jie, Chen, Shao‐Rui, Chen, Hong, Pan, Hui‐Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418757/
https://ncbi.nlm.nih.gov/pubmed/30578671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277428
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