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Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells

Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central to improving patient outcome. Hemopoietic stem cell transplantation (SCT) often establishes “mixed chimerism” in which immune cells from bot...

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Pubblicato in:Blood Adv
Autori principali: Kinsella, Francesca A. M., Zuo, Jianmin, Inman, Charlotte F., Pearce, Hayden, Maggs, Luke, Eldershaw, Suzy E., Chan, Y. L. Tracey, Nunnick, Jane, Nagra, Sandeep, Griffiths, Mike, Craddock, Charles, Malladi, Ram, Moss, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418492/
https://ncbi.nlm.nih.gov/pubmed/30824417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025502
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