Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells

Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central to improving patient outcome. Hemopoietic stem cell transplantation (SCT) often establishes “mixed chimerism” in which immune cells from bot...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Kinsella, Francesca A. M., Zuo, Jianmin, Inman, Charlotte F., Pearce, Hayden, Maggs, Luke, Eldershaw, Suzy E., Chan, Y. L. Tracey, Nunnick, Jane, Nagra, Sandeep, Griffiths, Mike, Craddock, Charles, Malladi, Ram, Moss, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418492/
https://ncbi.nlm.nih.gov/pubmed/30824417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025502
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