Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells

Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central to improving patient outcome. Hemopoietic stem cell transplantation (SCT) often establishes “mixed chimerism” in which immune cells from bot...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Kinsella, Francesca A. M., Zuo, Jianmin, Inman, Charlotte F., Pearce, Hayden, Maggs, Luke, Eldershaw, Suzy E., Chan, Y. L. Tracey, Nunnick, Jane, Nagra, Sandeep, Griffiths, Mike, Craddock, Charles, Malladi, Ram, Moss, Paul
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2019
Sujets:
Transplantation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418492/
https://ncbi.nlm.nih.gov/pubmed/30824417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025502
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