RNase HIII Is Important for Okazaki Fragment Processing in Bacillus subtilis

RNA-DNA hybrids are common in chromosomal DNA. Persistent RNA-DNA hybrids result in replication fork stress, DNA breaks, and neurological disorders in humans. During replication, Okazaki fragment synthesis relies on frequent RNA primer placement, providing one of the most prominent forms of covalent...

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Udgivet i:J Bacteriol
Main Authors: Randall, Justin R., Nye, Taylor M., Wozniak, Katherine J., Simmons, Lyle A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416905/
https://ncbi.nlm.nih.gov/pubmed/30670546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00686-18
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