A ligand-induced structural change in fatty acid–binding protein 1 is associated with potentiation of peroxisome proliferator–activated receptor α agonists

Peroxisome proliferator–activated receptor α (PPARα) is a transcriptional regulator of lipid metabolism. GW7647 is a potent PPARα agonist that must reach the nucleus to activate this receptor. In cells expressing human fatty acid–binding protein 1 (FABP1), GW7647 treatment increases FABP1's nuc...

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Udgivet i:J Biol Chem
Main Authors: Patil, Rahul, Mohanty, Biswaranjan, Liu, Bonan, Chandrashekaran, Indu R., Headey, Stephen J., Williams, Martin L., Clements, Craig S., Ilyichova, Olga, Doak, Bradley C., Genissel, Patrick, Weaver, Richard J., Vuillard, Laurent, Halls, Michelle L., Porter, Christopher J. H., Scanlon, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416440/
https://ncbi.nlm.nih.gov/pubmed/30598509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006848
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