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Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1
Interactions between secreted immune proteins called chemokines and their cognate G protein–coupled receptors regulate the trafficking of leukocytes in inflammatory responses. The two-site, two-step model describes these interactions. It involves initial binding of the chemokine N-loop/β3 region to...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6416418/ https://ncbi.nlm.nih.gov/pubmed/30567735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006535 |
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