Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

Interactions between secreted immune proteins called chemokines and their cognate G protein–coupled receptors regulate the trafficking of leukocytes in inflammatory responses. The two-site, two-step model describes these interactions. It involves initial binding of the chemokine N-loop/β3 region to...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Sanchez, Julie, e Huma, Zil, Lane, J. Robert, Liu, Xuyu, Bridgford, Jessica L., Payne, Richard J., Canals, Meritxell, Stone, Martin J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416418/
https://ncbi.nlm.nih.gov/pubmed/30567735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006535
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