Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Platelets contract forcefully after their activation, contributing to the strength and stability of platelet aggregates and fibrin clots during blood coagulation. Viscoelastic approaches can be used to assess platelet-induced clot strengthening, but they require thrombin and fibrin generation and ar...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ting, Lucas H., Feghhi, Shirin, Taparia, Nikita, Smith, Annie O., Karchin, Ari, Lim, Esther, John, Alex St., Wang, Xu, Rue, Tessa, White, Nathan J., Sniadecki, Nathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416331/
https://ncbi.nlm.nih.gov/pubmed/30867419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09150-9
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