Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

The Polycomb group (PcG) protein family is a well-known group of epigenetic modifiers. We used zebrafish to investigate the role of Rnf2, the enzymatic subunit of PRC1. We found a positive correlation between loss of Rnf2 and upregulation of genes, especially of those whose promoter is normally boun...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Chrispijn, Naomi D., Elurbe, Dei M., Mickoleit, Michaela, Aben, Marco, de Bakker, Dennis E.M., Andralojc, Karolina M., Huisken, Jan, Bakkers, Jeroen, Kamminga, Leonie M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416260/
https://ncbi.nlm.nih.gov/pubmed/30867528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40867-1
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