(−)-P7C3-S243 protects a rat model of Alzheimer’s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia.

BACKGROUND: In addition to cognitive deficits, Alzheimer’s disease (AD) is also associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, the field has seen only minimal therapeutic advances,...

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Bibliografiska uppgifter
I publikationen:Biol Psychiatry
Huvudupphovsmän: Voorhees, Jaymie R, Remy, Matthew T, Cintrón-Pérez, Coral J, El Rassi, Eli, Kahn, Michael Z, Dutca, Laura M, Yin, Terry C, McDaniel, Latisha M, Williams, Noelle S, Brat, Dan J, Pieper, Andrew A
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415524/
https://ncbi.nlm.nih.gov/pubmed/29246437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.10.023
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