(−)-P7C3-S243 protects a rat model of Alzheimer’s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia.

BACKGROUND: In addition to cognitive deficits, Alzheimer’s disease (AD) is also associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, the field has seen only minimal therapeutic advances,...

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Библиографические подробности
Опубликовано в: :Biol Psychiatry
Главные авторы: Voorhees, Jaymie R, Remy, Matthew T, Cintrón-Pérez, Coral J, El Rassi, Eli, Kahn, Michael Z, Dutca, Laura M, Yin, Terry C, McDaniel, Latisha M, Williams, Noelle S, Brat, Dan J, Pieper, Andrew A
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415524/
https://ncbi.nlm.nih.gov/pubmed/29246437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.10.023
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