Non-transpeptidase binding arylthioether β-Lactams active against Mycobacterium tuberculosis and Moraxella catarrhalis

The prevalence of drug resistance in both clinical and community settings as a consequence of alterations of biosynthetic pathways, enzymes or cell wall architecture is a persistent threat to human health. We have designed, synthesized, and tested a novel class of monocyclic β-lactams that carry an...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Beck, Tim N., Lloyd, Dina, Kuskovsky, Rostislav, Minah, Jeanette, Arora, Kriti, Plotkin, Balbina J., Green, Jacalyn M., Boshoff, Helena I., Barry, Clifton, Deschamps, Jeffrey, Konaklieva, Monika I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415315/
https://ncbi.nlm.nih.gov/pubmed/25549898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.11.025
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