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Multisite phosphorylation of S6K1 directs a kinase phospho-code that determines substrate selection
Multisite phosphorylation of kinases can induce on-off or graded regulation of catalytic activity; however, its influence on substrate specificity remains unclear. Here we show multisite phosphorylation of ribosomal protein S6 kinase 1 (S6K1) alters target selection. Agonist-inducible phosphorylatio...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6415305/ https://ncbi.nlm.nih.gov/pubmed/30612880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.017 |
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