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A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the formation of toxic amyloid-β (Aβ) oligomers and plaques. Considering that Aβ misfolding and aggregation precedes the progressive development of cognitive impairment in AD, investigating a therapeutic means by c...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414664/ https://ncbi.nlm.nih.gov/pubmed/30862818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40205-5 |
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