Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms including the development of highly aggressive, small cell neuroendocrine carcinoma (SCNC). SCNC patients have a dismal prognosis due in part to a limited underst...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Park, Jung Wook, Lee, John K., Sheu, Katherine M., Wang, Liang, Balanis, Nikolas G., Nguyen, Kim, Smith, Bryan A., Cheng, Chen, Tsai, Brandon L., Cheng, Donghui, Huang, Jiaoti, Kurdistani, Siavash K., Graeber, Thomas G., Witte, Owen N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414229/
https://ncbi.nlm.nih.gov/pubmed/30287662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat5749
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