Frequent clonal relations between metastases and non-index prostate cancer lesions

Primary prostate cancer lesions are clonally heterogeneous and often arise independently. In contrast, metastases were reported to share a monoclonal background. Because prostate cancer mortality is the consequence of distant metastases, prevention of metastatic outgrowth by primary tumor ablation i...

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Udgivet i:JCI Insight
Main Authors: Kneppers, Jeroen, Krijgsman, Oscar, Melis, Monique, de Jong, Jeroen, Peeper, Daniel S., Bekers, Elise, van der Poel, Henk G., Zwart, Wilbert, Bergman, Andries M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413780/
https://ncbi.nlm.nih.gov/pubmed/30674724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124756
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