Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche

Tumor radioresistance leading to local therapy failure remains a major obstacle for successful treatment of high-grade glioma. We hypothesized that distinct radiobiological features of particle therapy with carbon ions may circumvent glioma radioresistance. We demonstrate that carbon irradiation (CI...

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Udgivet i:JCI Insight
Main Authors: Chiblak, Sara, Tang, Zili, Lemke, Dieter, Knoll, Maximilian, Dokic, Ivana, Warta, Rolf, Moustafa, Mahmoud, Mier, Walter, Brons, Stephan, Rapp, Carmen, Muschal, Stefan, Seidel, Philipp, Bendzsus, Martin, Adeberg, Sebastian, Wiestler, Otmar D., Haberkorn, Uwe, Debus, Jürgen, Herold-Mende, Christel, Wick, Wolfgang, Abdollahi, Amir
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413779/
https://ncbi.nlm.nih.gov/pubmed/30674721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123837
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