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Microwave-Assisted Extraction of Multiple Trace Levels of Intermediate Metabolites for Camptothecin Biosynthesis in Camptotheca acuminata and Their Simultaneous Determination by HPLC-LTQ-Orbitrap-MS/MS and HPLC-TSQ-MS

Camptothecin (CPT) has strong antitumor activity and is used as an anticancer therapeutic agent. To better understand and decipher the pathway of CPT biosynthesis in Camptotheca acuminata, the main purpose here was focused on creating an effective extraction strategy for a rich intermediate metaboli...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Jin, Zhaoxia, Wan, Ruyi, Yan, Ruxue, Su, Yingying, Huang, Honglan, Zi, Lihan, Yu, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413206/
https://ncbi.nlm.nih.gov/pubmed/30823523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24040815
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