Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata

Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and expression data with reverse genetics, biochemistry, and metabolite profiling. RNAi silencing of enzymes r...

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Detalhes bibliográficos
Publicado no:Plant Cell
Main Authors: Sadre, Radin, Magallanes-Lundback, Maria, Pradhan, Sujana, Salim, Vonny, Mesberg, Alex, Jones, A. Daniel, DellaPenna, Dean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Plant Biologists 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006703/
https://ncbi.nlm.nih.gov/pubmed/27432874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1105/tpc.16.00193
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