Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata

Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and expression data with reverse genetics, biochemistry, and metabolite profiling. RNAi silencing of enzymes r...

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Bibliografische gegevens
Gepubliceerd in:Plant Cell
Hoofdauteurs: Sadre, Radin, Magallanes-Lundback, Maria, Pradhan, Sujana, Salim, Vonny, Mesberg, Alex, Jones, A. Daniel, DellaPenna, Dean
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Plant Biologists 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006703/
https://ncbi.nlm.nih.gov/pubmed/27432874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1105/tpc.16.00193
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