Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling

BACKGROUND: Hepatic fibrosis is caused by chronic liver injury and may progress toward liver cirrhosis, and even hepatocellular carcinoma. However, current treatment is not satisfactory. Therefore, there is a mandate to find novel therapeutic targets to improve therapy, and biomarkers to monitor the...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Li, Jun, Wang, Yahui, Ma, Mingze, Jiang, Shuheng, Zhang, Xueli, Zhang, Yanli, Yang, Xiaomei, Xu, Chunjie, Tian, Guangang, Li, Qing, Wang, Yang, Zhu, Lei, Nie, Huizhen, Feng, Mingxuan, Xia, Qiang, Gu, Jianren, Xu, Qing, Zhang, Zhigang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412555/
https://ncbi.nlm.nih.gov/pubmed/30639416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.009
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