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CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus
Mounting evidence in the literature suggests that RNA–RNA binding protein aggregations can disturb neuronal homeostasis and lead to symptoms associated with normal aging as well as dementia. The specific ablation of cyclin A2 in adult neurons results in neuronal polyribosome aggregations and learnin...
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| Publicado no: | Am J Pathol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6412465/ https://ncbi.nlm.nih.gov/pubmed/30579783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.10.020 |
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