Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice

Defects in Fas function correlate with susceptibility to systemic autoimmune diseases like autoimmune lymphoproliferative syndrome (ALPS) and systemic lupus erythematosus (SLE). C57BL/6 lpr (B6/lpr) mice are used as an animal model of ALPS and develop a mild SLE phenotype. Involvement of interleukin...

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Udgivet i:Sci Rep
Main Authors: Corneth, Odilia B. J., Schaper, Fleur, Luk, Franka, Asmawidjaja, Patrick S., Mus, Adriana M. C., Horst, Gerda, Heeringa, Peter, Hendriks, Rudi W., Westra, Johanna, Lubberts, Erik
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412096/
https://ncbi.nlm.nih.gov/pubmed/30858513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39483-w
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