Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis

Vasculogenesis and angiogenesis are process of formation of blood vessels. Blood vessels are evolved to distribute nutrients and oxygen to distant organs. These vessels are crucial for growth and repair of wounded tissue. During tumor condition there occurs imbalance in the growth of blood vessels w...

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Udgivet i:Sci Rep
Main Authors: Kajal, Kirti, Panda, Abir K., Bhat, Jyotsna, Chakraborty, Dwaipayan, Bose, Sayantan, Bhattacharjee, Pushpak, Sarkar, Tania, Chatterjee, Subhrangsu, Kar, Santosh K., Sa, Gaurisankar
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412047/
https://ncbi.nlm.nih.gov/pubmed/30858542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40626-2
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