The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells

Estrogen/ERα signaling is critical for breast cancer progression and therapeutic treatments. Thus, identifying new regulators of this pathway will help to develop new therapeutics to overcome chemotherapy resistance of the breast cancer cells. Here, we report Ajuba directly interacts with ERα to pot...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Xu, Beihui, Li, Qi, Chen, Ning, Zhu, Chunxiao, Meng, Qingrong, Ayyanathan, Kasirajan, Qian, Wenli, Jia, Hao, Wang, Jiamin, Ni, Peihua, Hou, Zhaoyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412004/
https://ncbi.nlm.nih.gov/pubmed/30597111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1306
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