The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells

Estrogen/ERα signaling is critical for breast cancer progression and therapeutic treatments. Thus, identifying new regulators of this pathway will help to develop new therapeutics to overcome chemotherapy resistance of the breast cancer cells. Here, we report Ajuba directly interacts with ERα to pot...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Xu, Beihui, Li, Qi, Chen, Ning, Zhu, Chunxiao, Meng, Qingrong, Ayyanathan, Kasirajan, Qian, Wenli, Jia, Hao, Wang, Jiamin, Ni, Peihua, Hou, Zhaoyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412004/
https://ncbi.nlm.nih.gov/pubmed/30597111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1306
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