The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells

Estrogen/ERα signaling is critical for breast cancer progression and therapeutic treatments. Thus, identifying new regulators of this pathway will help to develop new therapeutics to overcome chemotherapy resistance of the breast cancer cells. Here, we report Ajuba directly interacts with ERα to pot...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Xu, Beihui, Li, Qi, Chen, Ning, Zhu, Chunxiao, Meng, Qingrong, Ayyanathan, Kasirajan, Qian, Wenli, Jia, Hao, Wang, Jiamin, Ni, Peihua, Hou, Zhaoyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412004/
https://ncbi.nlm.nih.gov/pubmed/30597111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1306
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