Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer

The therapeutic landscape of castration-resistant prostate cancer (CRPC) has rapidly expanded. There is a need to develop noninvasive biomarkers to guide treatment. We established a highly sensitive method for analyzing androgen receptor gene (AR) copy numbers (CN) and mutations in plasma circulatin...

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Pubblicato in:Sci Rep
Autori principali: Sumiyoshi, Takayuki, Mizuno, Kei, Yamasaki, Toshinari, Miyazaki, Yu, Makino, Yuki, Okasho, Kosuke, Li, Xin, Utsunomiya, Noriaki, Goto, Takayuki, Kobayashi, Takashi, Terada, Naoki, Inoue, Takahiro, Kamba, Tomomi, Fujimoto, Akihiro, Ogawa, Osamu, Akamatsu, Shusuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411952/
https://ncbi.nlm.nih.gov/pubmed/30858508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40719-y
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