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Dynamic analysis of human tyrosinase intra-melanosomal domain and mutant variants to further understand oculocutaneous albinism type 1

Human tyrosinase (Tyr) is a Type I membrane glycoprotein that is the rate-limiting enzyme for controlling the production of melanin pigment in melanosomes. Currently, ~300 Tyr mutations are known to be involved in the genetic disease oculocutaneous albinism type 1 (OCA1), which exists in two forms,...

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Detalhes bibliográficos
Publicado no:J Anal Pharm Res
Main Authors: Farney, S Katie, Dolinska, Monika B, Sergeev, Yuri V
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411056/
https://ncbi.nlm.nih.gov/pubmed/30868138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15406/japlr.2018.07.00293
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