Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bretones, Gabriel, Álvarez, Miguel G., Arango, Javier R., Rodríguez, David, Nadeu, Ferran, Prado, Miguel A., Valdés-Mas, Rafael, Puente, Diana A., Paulo, Joao A., Delgado, Julio, Villamor, Neus, López-Guillermo, Armando, Finley, Daniel J., Gygi, Steven P., Campo, Elías, Quesada, Víctor, López-Otín, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410914/
https://ncbi.nlm.nih.gov/pubmed/30181176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-804401
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