Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

The combination of immune checkpoint blockade with chemotherapy is currently under investigation as a promising strategy for the treatment of triple negative breast cancer (TNBC). Tumor-associated macrophages (TAMs) are the most prominent component of the breast cancer microenvironment because they...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Roux, Cecilia, Jafari, Soode Moghadas, Shinde, Rahul, Duncan, Gordon, Cescon, David W., Silvester, Jennifer, Chu, Mandy F., Hodgson, Kelsey, Berger, Thorsten, Wakeham, Andrew, Palomero, Luis, Garcia-Valero, Mar, Pujana, Miguel A., Mak, Tak W., McGaha, Tracy L., Cappello, Paola, Gorrini, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410837/
https://ncbi.nlm.nih.gov/pubmed/30770442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819473116
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