Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in PTEN, gain-of-...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Terakawa, Jumpei, Serna, Vanida Ann, Taketo, Makoto Mark, Daikoku, Takiko, Suarez, Adrian A., Kurita, Takeshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2019
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410785/
https://ncbi.nlm.nih.gov/pubmed/30782821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814506116
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