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CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for refractory B cell malignancies, especially acute lymphoblastic leukemia (ALL)1. While a majority of patients will achieve a complete response following a single infusion of CD19 CAR T cells(2–4), the broad applicabi...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Giavridis, Theodoros, van der Stegen, Sjoukje J. C., Eyquem, Justin, Hamieh, Mohamad, Piersigilli, Alessandra, Sadelain, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410714/
https://ncbi.nlm.nih.gov/pubmed/29808005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0041-7
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