Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study the 18-mer amphiphilic PN159 peptide was foun...

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Publicado no:Pharmaceutics
Main Authors: Bocsik, Alexandra, Gróf, Ilona, Kiss, Lóránd, Ötvös, Ferenc, Zsíros, Ottó, Daruka, Lejla, Fülöp, Lívia, Vastag, Monika, Kittel, Ágnes, Imre, Norbert, Martinek, Tamás A., Pál, Csaba, Szabó-Révész, Piroska, Deli, Mária A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410202/
https://ncbi.nlm.nih.gov/pubmed/30744154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11020073
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